Biophysicist by training, I am adopting a holistic systems biology approach to understand how normal and aberrant cellular decisions are made in the brain

Nam is a computer scientist, working on the development of biophysics-oriented and ML approaches for cross-dementia trajectory reconstruction.

Marle is investigating the (dysregulation of) isoform choice in the human brain across dementia conditions, leveraging and developing multimodal experimental and computational approaches.

Helen is developing and applying experimental and computational methods to study the genetic determinants of chromatin activity and connectivity in the neuroimmune context.

Lai Ting is providing us A-Z support with the generation of multimodal single-cell and bulk data, such as chromatin organization data, using 4C and (C)Hi-C approaches, as well as with the experimental validation, using CRISPR-mediated perturbation assays.

Noémie is using chromatin organisation assays and other omics techniques to understand the regulatory logic underlying isoform choice upon cell fate acquisition.

Ruoxin is a joint computational PhD student (shared with the awesome Pasciuto Lab), investigating intercellular immune cell atlas in the human brain in health and dementia.

Margo is a computational PhD student, investigating they key factors behind Alzheimer's disease progression using multi-modal foundation models and causal theory.

Lunky is a PhD student at the intersection of applied mathematics, AI and neuroscience. He is developing and applying causal theory and generative AI approaches for studying the development of neurodegenerative diseases.

Sriya is developing and optimizing single-cell chromatin interaction strategies in mouse and human brain tissue. My broader goal is to understand how spatial genome organization constrains transcriptional programs in complex neural systems.

Lance generates vascularised neuroimmune organoids to study neurodegenerative disorders, as a joint Postdoc between the Malysheva and Sleegers lab.